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科研教学

赵世民

 

赵世民/教授
 
专业名称:生物化学与分子生物学 导师类别:博导/硕导
 
研究方向:代谢物的感知与信号传导、代谢物信号失调的致病机理 E-mail:zhaosm@fudan.edu.cn
 
 
 
1 个人经历 起止年月 工作单位 职称/职务
 

2016/01-至今

2006/01-至今

2000/07-2005/12

复旦大学附属妇产科医院

复旦大学

美国宝洁(Procter& Gamble)公司

教授/研究所所长

教授

科学家/亚洲业务总监

 
   
2 科研成果 近五年代表性论文(第一或通讯作者)
(需列出论文题目,发表期刊,期刊卷号,SCI请列出IF)
 
 

1、Hu Song-Hua, Feng Yu-Yang, Yang Yuan-Xin,  Ma Hui-Da, Zhou Shu-Xian,  Qiao Ya-Nan,  Zhang Kai-Hui, Zhang Lei, Huang Lin, Yuan Yi-Yuan,  Lin Yan, Zhang Xin-Yan,  Li  Yao,  Li Hai-Tao, Zhao Jian-Yuan, * Xu Wei, * Zhao Shi-Min. *Amino acids downregulate SIRT4 to detoxify ammonia through the urea cycle. (2023) Nature Metabolism, 5, 626-641(IF:19.865)

2、Zhao Rui, Cai Ke, Yang Jing-Jing, Zhou Qian, Cao Wei, Xiang Jie, Shen Yi-Hui, Cheng Lei-Lei, Zang Wei-Dong, Lin Yan, Yuan Yi-Yuan, Xu Wei, Tao Hui, * Zhao Shi-Min, *Zhao Jian-Yuan*. Nuclear ATR lysine-tyrosylation protects against heart failure by activating DNA damage response.(2023) Cell Reports,43,4,112400(IF:9.995)

3、Jianyong Du, Lixia Zheng, Peng Gao, Hang Yang, Wan-Jie Yang, Fusheng Guo, Ruqi Liang, Mengying Feng, Zihao Wang, Zongwang Zhang, Linlu Bai, Ye Bu, Shijia Xing, Wen Zheng, Xuelian Wang, Li Quan, Xinli Hu, Haosen Wu, Zhixing Chen, Liangyi Chen, Ke Wei, Zhe Zhang, Xiaojun Zhu, Xiaolin Zhang, Qiang Tu, Shi-Min Zhao, * Xiaoguang Lei, * and Jing-Wei Xiong*. A small-molecule cocktail promotes mammalian cardiomyocyte proliferation and heart regeneration. (2022) Cell Stem Cell,29,545-558(IF:25.269)

4、Qian Zhou, Wan-Wan Sun, Jia-Cong Chen, Hui-Lu Zhang, Jie Liu, Yan Lin, Peng-Cheng Lin, Bai-Xing Wu, Yan-Peng An, Lin Huang, Wen-Xing Sun, Xin-Wen Zhou, Yi-Ming Li, Yi-Yuan Yuan, Jian-Yuan Zhao, Wei Xu, * Shi-Min Zhao*. Phenylalanine impairs insulin signaling and inhibits glucose uptake through modification of IRβ.(2022) Nature Communications 13:4291(IF:17.694)

5、Song-Hua Hu, Xia-Di He, Ji Nie, Jun-Li Hou, Jiang Wu, Xiao-Yan Liu, Yun Wei, Hui-Ru Tang,Wen-Xing Sun, Shu-Xian Zhou, Yi-Yuan Yuan, Yan-Peng An, Guo-Quan Yan, Yan Lin, Peng-Cheng Lin,Jean J. Zhao, Ming-Liang Ye, * Jian-Yuan Zhao, * Wei Xu, * and Shi-Min Zhao, * Methylene-bridge tryptophan fatty acylation regulates PI3K-AKT signaling and glucose uptake.(2022) Cell Reports,38,110509(IF:9.995)

6、Rui Qin, Chen Zhao, Chen-Ji Wang, Wei Xu, Jian-Yuan Zhao, Yan Lin, Yi-Yuan Yuan, Peng-Cheng Lin, Yao Li, Shimin Zhao* , Yan Huang*.Tryptophan potentiates CD8+ T cells against cancer cells by TRIP12 tryptophanylation and surface PD-1 downregulation.(2021) Journal For Immunotherapy Of Cancer,Vol 9,7(IF:12.469)

7、Jiao-Jiao Zhang, Ting-Ting Fan, Yun-Zi Mao, Jun-Li Hou, Meng Wang, Min Zhang, Yan Lin, Lei Zhang, Guo-Quan Yan, Yan-Peng An, Jun Yao, Cheng Zhang , Peng-Cheng Lin, Yi-Yuan Yuan, Jian-Yuan Zhao, Wei Xu* , Shi-Min Zhao*.Nuclear dihydroxyacetone phosphate signals nutrient sufficiency and cell cycle phase to global histone acetylation.(2021) Nature Metabolism, Vol 3,6,859(IF:19.865)

8、Xinyu Mei# , Dashi Qi#, Ting Zhang#, Ying Zhao#, Li Jin, Junli Hou, Jianhua Wang,Yan Lin, Yu Xue , Pingping Zhu, Zexian Liu , Lei Huang, Ji Nie, Wen Si, Jingyi Ma,Jianhong Ye, Richard H Finnell, Hexige Saiyin, Hongyan Wang *, Jianyuan Zhao*, Shimin Zhao*, Wei Xu*. Inhibiting MARSs reduces Hyperhomocysteinemia-associated neural tube and congenital heart defects. (2020) EMBO Molecular Medicine, Vol 12,3,e9469(IF:14.260)

9、Yuan-Yuan Qu, Rui Zhao, Hai-Liang Zhang, Qian Zhou, Fu-Jiang Xu, Xuan Zhang, Wen-Hao Xu, Ning Shao, Shu-Xian Zhou, Bo Dai, Yao Zhu, Guo-Hai Shi, Yi-Jun Shen, Yi-Ping Zhu, Cheng-Tao Han, Kun Chang, Yan Lin, Wei-Dong Zang, Wei Xu, Ding-Wei Ye*, Shi-Min Zhao*, and Jian-Yuan Zhao*. Inactivation of the AMPK–GATA3–ECHS1 Pathway Induces Fatty Acid Synthesis That Promotes Clear Cell Renal Cell Carcinoma Growth. (2020) Cancer Research, Vol80,2,319-333(IF:13.312)

10、Yang Li, Cui-Fang Yao, Fu-Jiang Xu, Yuan-Yuan Qu, Jia-Tao Li, Yan Lin, Zhong-Lian Cao,Peng-Cheng Lin, Wei Xu, Shi-Min Zhao*, Jian-Yuan Zhao* APC/CCDH1 synchronizes ribose-5-phosphate levels and DNA synthesis to cell cycle progression. (2019)Nature communications,10:2502(IF:17.694)

 

近五年获奖情况

奖项类别:第二十一届吴阶平-保罗.杨森医学药学奖  主要完成人:赵世民

 
   
 
           
aa 承担项目
项目起止年份 立项经费(万元) 项目名称 项目来源
2023/1-2027/12 267 线粒体蛋白质乳酰化修饰调控酶的调控机制及生理/病理意义 国家自然科学基金重点项目
2023/1-2025/12 800 代谢物蛋白质修饰的生理病理及化学干预 国家自然科学基金重大研究计划集成项目
2020/1-2024/12 309 抑制胰岛素受体酪氨酰修饰的胰岛素信号增敏新策略氨酰修饰 国家自然科学基金重点项目
2019/9-2024/8 2005 组织器官发育中重要新型代谢物鉴定及其功能 科技部重点研发计划
2019/1-2024/12 1050 代谢生物化学 国家自然科学基金创新研究群体项目
 
 
 
 
 
         
           
aa 学会/杂志任职
任职学会 职务 任期起始时间 任期终止时间
中国生物化学与分子生物学会 常务委员 2018/10/26 2023/10/25
生化学会酶学专业分会 副主任委员 2019/8/10 2023/8/9
生化学会肿瘤代谢专业委员会 副主任委员 2018/8/17 2023/8/16
蛋白质专业分会 委员 2022/12/17 2026/12/16
任职期刊 职务 任期起始时间 任期终止时间
Signal Transduction and Targeted Therapy Editorial Board 2019/1/1 2024/12/31
Nutrition & Metabolism Associate Editor 2018/1/1 2023/12/31
Cellular and Molecular Life Sciences Editorial Board 2019/1/1 2024/12/31
Metabolites Editorial Board 2019/1/1 2024/12/31
复旦学报(医学版) 编委 2018/6/1 2024/5/31
复旦学报(自科学版) 生命科学终审编委 2018/6/1 2024/5/31