员工通道 ENGLISH

科研教学

杜美蓉

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杜美蓉 / 博士后  
 
专业名称:妇产科学 导师类别:博导
 
研究方向:生殖免疫、生殖内分泌 E-mail: mrdu#fudan.edu.cn
1 个人经历 起止年月 职称/职务 工作单位
 

2017.1——至今

复旦大学附属妇产科医院

研究所副所长

2014.12—至今

复旦大学附属妇产科医院

研究员、主任医师

2015.10——至今

2009.5-2014.12

2007.9-2009.11

2005.7-2007.9

2002.9-2005.6

1999.9-2002.5

1991.9-1996.6

复旦大学附属妇产科医院

复旦大学附属妇产科医院

加拿大渥太华大学

复旦大学附属妇产科医院

复旦大学附属妇产科医院

东南大学医学院

扬州大学医学院

研究员、主任医师、博导

副研究员、副主任医师、硕导

博士后

主治医师

博士生

硕士生

本科生

 
 
2 研究成果

近五年代表性论文(第一或通讯作者)

 
 

1

1.Li YH#, Zhang D#, Xu L#, Dong L, Zheng J, Lin YK, Huang JF, Zhang YY, Tao Y, Zang XX, Li DJ, and Du MR*. Cell-cell contact with proinflammatory macrophages enhances the immunotherapeutic effect by mesenchymal stem cells in two abortion models.Cell Mol Immunol. Accepted 2019. (IF:7.551)


2.Wang SC#, Chen CQ#, Li MD, Qian Jf, Sun FY, Li YY, Yu M, Wang MY, Zang XX, Zhu R, Li DJ, Du MR*. Blockade of CTLA-4 and Tim-3 pathways induces fetal loss with altered cytokine profiles by decidual CD4+T cells. Cell Death & Disease. 2019 in proof IF:5.638


3.Wang SC#, Sun FR#, Han MT, Liu YH, Zou QY, Wang FX, Tao Y, Li DJ, Du MR*, Li H, Zhu R*. Trophoblasts-Derived Hyaluronan Promotes the Regulatory Phenotype of Decidual Macrophages. Reproduction 2019. in proof IF:3.086


4.Li YY,Lin YK, Liu XH, Wang, Yu Min, Li DJ, Zhu YZ, Du MR*. Leonurine: from a gynecologic holy medicine to be multi- therapeutic agent. 2019, in proof IF:1.21


5.Sun FR, Chen CQ, Yu M, Wang SC*, Li DJ, Du MR* Galectin-9 promotes human trophoblast cell invasion via MMP-2 and p38 signaling. Journal of Reproductive and Developmental Medicine. 2018;2:1-7 IF:0.452


6.Sun FR#, Wang SC#, Li DJ, Du MR*. Iron Metabolism Regulation and Diseases. Gynaecology and Perinatology 1.3 (2018): 143-151.


7.Li YH, Li DJ, Du MR*.TIM-3: a crucial regulator of NK cells in pregnancy. Cell Mol Immunol 2017,14(11): 948-950. IF2017:5.193


8.Li YH#, Zhang JY#, Zhang D, Hong XW, Tao Y, Wang SC, Xu YY, Piao HL, Yin WJ, Yu M, Zhang Y, Fu Q, Li DJ, Chang X*, Du MR*. Tim-3 signaling in peripheral NK cells promotes maternal-fetal immune tolerance and prevents pregnancy loss. (Vol.10, pp.eaah4323). IF: 7.359

9.Xu YY#, Wang SC#, Lin YK#, Li DJ, DU MR*. Tim-3 and PD-1 regulate CD8+T cell function to maintain early pregnancy in mice. J Reprod Dev. 2017 Jun 21;63(3):289-294. IF:1.635

10.Xu YY#, Wang SC#, Li DJ, Du MR*.Co-Singling Molecules in Maternal-fetal Immunity.Trends Mol Med. 2017 Jan;23(1):46-58 (IF2017:11.021) 

11.Zhang D#, Piao HL#, Li YH#, Qiu Q, Li DJ, Du MR*, Tsang BK*. Inhibition of AKT sensitizes chemoresistant ovarian cancer cells to cisplatin by abrogating S and G2/M arrest. Exp Mol Pathol. 2016;100(3):506-513. IF:2.638

12.Ding XB, Liu GS, Xu B, Wu CQ, Hui N, Ni X, Wang J, Du MR*, Teng XM*, Wu J*. Human GV oocytes generated by mitotically active germ cells obtained from follicular aspirates. Sci Reports. 2016; 6:28218. IF: 5.228

13.Wang SC#, Zhu XY#, Xu YY#, Zhang D, Li YH, Tao Y, Piao HL, Li DJ*, Du MR*. Programmed cell death 1 (PD-1) and T-cell immunoglobulin mucin-3 (Tim-3) regulate CD4+ T cells to induce type 2 helper T cell(Th2) bias at the maternal-fetal interface. Hum Reprod. 2016;31(4):700-11. IF: 4.621

14.Li YH, Zhou WH, Tao Y, Wang SC, Jiang YL, Zhang D, Piao HL, Fu Q, Li DJ, Du MR*. The Galectin-9/Tim-3 pathway is involved in the regulation of NK cell function at the maternal-fetal interface in early pregnancy. Cell Mol Immunol. 2016;13(1):73-81.IF:5.193

15.Piao HL, Wang SC, Tao Y, Fu Q, Du MR*, Li DJ*. CXCL12/CXCR4 signal involved in the regulation of trophoblasts on peripheral NK cells leading to Th2 bias at the maternal-fetal interface. Eur Rev Med Pharmacol Sci. 2015;19(12):2153-61. IF:1.575

16.Zhou WH*, Wu X, Hu WD, Du MR*. Co-expression of CXCR4 and CXCR7 in human endometrial stromal cells is modulated by steroid hormones. Int J Clin Exp Pathol. 2015;8(3):2449-60. IF:1.581

17.Wang SC, Li YH, Piao HL, Hong XW, Zhang D, Xu YY, Tao Y, Wang Y, Yuan MM, Li DJ, Du MR*. PD-1 and Tim-3 pathways are associated with regulatory CD8+ T cell function in decidua and maintenance of normal pregnancy. Cell Death & Disease 2015;6:e1738. IF:5.378


18.Wang SC#, Cao CM#, Piao HL, Li YH, Tao Y, Zhang XM, Zhang D, Sun C, Zhu R, Wang Y, Yuan MM, Li DJ, Du MR*. Tim-3 protects decidual stromal cells from toll-like receptor-mediated apoptosis and inflammatory reactions and promotes Th2 bias at the maternal-fetal interface. Sci Rep. 2015 Mar 11;5:9013. IF:5.228


19.Du DF, Li XL*, Fang F, Du MR. Expression of anti-Müllerian hormone in letrozole rat model of polycystic ovary syndrome. Gynecol Endocrinol. 2014:1-5. IF:1.413


20.Tao Y, Li YH, Piao HL, Zhou WJ, Zhang D, Du Q, Wang SC, Li DJ*, Du MR*. CD56brightCD25+NK cells preferentially distribute at maternal-fetal interface in human early pregnancy. Cell Mol Immunol. 2015;12(1):77-86    IF:7.511


21.Zhang Y, Yang C, Fu S, Chen X, Zhang S, Li Y, Du M*, Zhang J*. Different expression of NOD2 in decidual stromal cells between normal and unexplained recurrent spontaneous abortion women during first trimester gestation. Int J Clin Exp Pathol. 2014;7(12):8784-90. eCollection 2014. IF: 1.581


22.Tang Chl; Liang J; Qian, Jf, Jin LP, Du MR, Li MQ, Li DJ. Opposing role of JNK-p38 kinase and ERK1/2 in hydrogen peroxide-induced oxidative damage of human trophoblast-like JEG-3 cells. Int J ExpPathol. 2014 Feb 15;7(3):959-68. eCollection 2014. IF:1.581


23.Zhang YY, Chen H, Sun C, Wang HZ, Liu ML, Li YY, Nie XL, Du MR, Li DJ*, Zhang JP*. Expression and functional characterization of NOD2 in decidual stromal cells isolated during the first trimester of pregnancy. PLoS One. 2014; 9(6):e99612. IF:3.057


24.Du MR*, Wang SC, Li DJ*. The integrative roles of chemokines at the maternal-fetal interface in early pregnancy. Cell Mol Immunol. 2014;11(5):438-448 (Invited review)IF: 5.193 


25.Huang YH, Ma YL, Ma L, Mao JL, Zhang Y, Du MR*, Li DJ*. Cyclosporine A improves adhesion and invasion of mouse preimplantation embryos via upregulating integrin β3 and matrix metalloproteinase -9. Int J Clin Exp Pathol 2014, 7(4):1379-88. IF:1.581


26.Fu Q, Tao Y, Piao HL, Du MR*, Li DJ*. Trophoblasts and Decidual Stromal Cells Regulate Decidual NK Cell Functions Via Interaction between Collagen and LAIR-1. Am J Reprod Immunol. 2014; 71(4):368-378. IF:2.916


27.Du MR, Guo PF, Piao HL, Wang SC, Sun C, Li YH, Jin LP, Tao Y, Zhang D, Zhu R, Fu Q, Li DJ*. Embryonic trophoblasts induce decidual regulatory T cell differentiation and maternal-fetal tolerance through TSLP instructing DCs. J Immunol. 2014;192(4):1502-1511 IF:4.985


28.Du MR*, Piao HL, Li DJ*. The 3rd International Conference on Reproductive Immunology in Shanghai: September 27–29, 2013. Shanghai, China. Am J Reprod Immunol. 2014; 71(3):203-209. IF: 2.916

  近五年获奖情况
   中华医学科技奖    二等奖    母胎免疫调节机制及其临床应用研究   (主要完成人)杜美蓉,李大金,金莉萍,朴海兰,朱晓勇,李明清,唐传玲,赵洪波

上海市医学科技奖    二等奖    母胎免疫调节机制及其临床应用研究   (主要完成人)杜美蓉,李大金,朴海兰,金莉萍,朱晓勇,李明清,唐传玲,赵洪波
  近五年获得专利情况
   
   
       

任职学会

美洲生殖免疫学会(ASRI)

中国生理学会

中国免疫学会生殖免疫学分会

中国妇幼健康

中国病理生理学会 免疫专委会

上海市免疫学会生殖免疫专委会

上海市医师协会整合医学分会

中国生理学会 生殖生物学专委会

 

任职期刊

AM J Reprod Immunol

职务

理事

理事

秘书长

常委

委员

 副主任委员

委员

委员


职务

副主编

任期起始时间

2018.6

2018.12

2013.6

2018.12

2018.3

2014.6

2018.1

2015.3

 

任期起始时间

2018.12

任期结束时间

至今

至今

至今

至今

至今

至今

至今

至今

 

任期结束时间

至今

 
         
         
aa 承担项目

2017.10-2020.12     人类胚胎着床调控及相关重大妊娠疾病发生机制     国家重点研发计划”生殖健康及重大出生缺陷防控研究重点专项2017YFC1001403     1300万元(本人72万)

2017.05.01-2020.04.29     蜕膜CXCR4+/CXCR3-NK细胞亚群平衡诱导母-胎免疫耐受与正常妊娠维持的分子机制      上海市科委:上海市优秀学术带头人计划     40万元

2018.1-今     母胎免疫调节机制及其临床应用研究     上海市领军人才计划     50万元

2017.1-2021.12     胚胎滋养细胞诱导母-胎免疫耐受维持正常妊娠的分子机制     国家自然科学基金重点项目     300万元

2016.1-2019.12     蜕膜CXCR4+与CXCR4-NK细胞在CD4+T细胞亚群平衡与母-胎免疫耐受中的调节作用     国家自然科学基金面上项目     60万元

2015.1-2019.12     母-胎界面交互对话异常致妊娠相关重大疾病的分子机制     国家重大研究计划973项目     2500万(本人90万)

2016.1-2018.12     胚胎滋养细胞诱导母-胎免疫耐受维持正常妊娠的分子机制     国家自然科学基金重大项目培育计划     70万元